Products

switchplex t790m visual

HB SwitchPlex™

T790M Kit

EGFR T790M Mutation test

RUO

Principle

Lung Cancer and EGFR T790M Mutation

About 85% of Lung cancer is Non Small Cell Lung Cancer (NSCLC), and 70% of NSCLC is caused by overexpression of epidermal growth factor receptor gene.

EGFR tyrosine kinase inhibitor (TKI) treatment significantly delays the progression of NSCLC, however, exon 20 T790M mutation is related to the acquired tolerance to TKI treatment. Therefore, patient prescribed with Gefitinib or Erlotinib needs regular monitoring of EGFR T790M mutation tests and patients with test positive for the mutation needs to change the prescription to Osimertinib.

EGFR TKI resistance occur in 50% of NSCLC patients within 6 months due to EGFR T790M mutation.

Mutation positive patients need proper prescription for targeted agents to treat the somatic mutation in early variation.

First-Line

Resistance

Second-Line

First-Line Treatment

Tyrosine Kinase Inhibitors (TKIs)

▲ Iressa

(gefitinib)

▲ Tarceva

(erlotinib)

※ Image source: Asan Medical Center (https://ni.amc.seoul.kr/asan/healthinfo/druginfo)

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First-Line Treatment

Approximately, 50% of patients develop Resistance in 6 months.

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Second-Line Treatment

※ Image source: Asan Medical Center (https://ni.amc.seoul.kr/asan/healthinfo/druginfo)

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Related Technology

HB SwitchPlex™ products are applied with Switching™-PCR Technology which detects target genes in low concentrations with high reproducibility and accuracy

(<10¹ copies PCR Template)

Switching™ PCR